Fig. 8
From: Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication
Introduction of CpG dinucleotides into gag inhibits HIV-1 replication in Jurkat cells. a The amount of HIV-1 CA (p24Gag) in supernatants from 293T cells transfected with pHIV-1NL4-3, pHIV-1 CpG22-165, pHIV-1 CpG22-261 or pHIV-1 CpG22-378 were quantified by p24Gag ELISA. The bar chart is the average of three independent experiments normalized to HIV-1NL4-3. Error bars represent standard deviation. b Jurkat cells were infected with 25Â ng of p24Gag for each indicated virus. The amount of infectious virus present at each time point was measured in TZM-bl cells. This is representative of three independent experiments