Table 3 Interacting Residues of PSF with viral dsDNA and Integrase
PSF with binary complex of HIV-1 IN–viral dsDNA | PSF with HIV-1 IN | ||
|---|---|---|---|
AA* of PSF | DsDNA | AA* of PSF | AA* of HIV-1 integrase |
K332 | PO4-backbone | F300 | M50 |
F300 | PO4-backbone | E310 | Y15 |
F327 | A25 | V326 | H16 |
N329 | A25 | F327 | H16 |
F334 | C30 | K330 | N18 |
| Â | Â | D386 | D64 |
| Â | Â | D454 | H51 |
| Â | Â | K332 | W19 |
R360 | PO4-backbone | F334 | A49 |
| Â | Â | T368 | Q48 |
T368 | PO4-backbone | Y381 | I141 |
A370 | T28 | Y381 | Q148 |
R409 | C20 | G408 | V54 |
E465 | T19 | R409 | V54 |
| Â | Â | D454 | H51 |
| Â | Â | L463 | Y143 |
| Â | Â | K466 | E146 |
| Â | Â | N467 | S147 |
| Â | Â | P468 | E152 |
| Â | Â | R409 | P145 |