Fig. 8
From: Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
CLK1 and CLK2 act at distinct steps to regulate HIV-1 gene expression. HIV-1 provirus integrated into the host genome is transcribed by the cellular RNA polymerase II (RNAP II). CLK1 acts to suppress the use of the HIV-1 promoter while CLK2 promotes steps in viral RNA synthesis/processing post initiation (elongation, splicing, or 3′ end formation)