Skip to main content
Fig. 5 | Retrovirology

Fig. 5

From: Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Fig. 5

Host viral restriction factors are increased by in vivo treatment with VX-765. RNA was extracted from spleen of rFLT-3 L-treated mice that were infected with HIV (n = 3) or infected with HIV and treated with VX-765 (n = 3) following tissue collection on day 14 as described in Fig. 3A. (A) The differential transcriptome of HIV-infected mouse spleen, due to VX-765 treatment, was determined through expression analysis and visualized in a volcano plot with cut-offs at a p-value of < 0.05. (B) RNA-Seq analysis further elucidated several HIV restriction factors which were up or down regulated in the spleen mice in the HIV + VX-765 group compared to the HIV group. (C, D) Reactome Pathway Analysis of the differentially expressed genes was performed using String-db.org. The graphs represent up and down regulated pathways and biological processes predicted to result from VX-765 treatment of HIV-infected animals

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us