Skip to main content
Fig. 6 | Retrovirology

Fig. 6

From: Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Fig. 6

Network analysis identifies immune pathway alterations in HIV-infected tissue due to VX-765 treatment. Interconnected pathways that are disrupted due to in vivo inhibition of caspase 1/4 were determined in HIV-infected HIS mice that were non-treated (n = 3) or treated with VX-765 (n = 3) as described in Fig. 3A. Significantly perturbed pathways were identified through Ingenuity Pathway Analysis of RNA-Seq data from spleen using p ≤ 0.001 and Z score ≥ + 2 for activation or p ≤ 0.001 and Z score ≤ -2 for suppression

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us