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Fig. 7 | Retrovirology

Fig. 7

From: Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue

Fig. 7

Graphical summary. Enhancements to the HIS mouse model that augment secondary lymphoid organs expand opportunities for experimentation to understand pathogenesis and test interventions in a small animal model of HIV-infection. Treatment with exogenous human rFLT-3 L promoted the development of LN and increased the relative abundance of human T cells in spleen of HIS mice. This advance permits investigations of HIV-mediated immune outcomes and tissue-level pathogenesis in highly relevant secondary lymphoid compartments. Targeting the inflammasome cascade in rFLT-3 L-treated and HIV-infected HIS mice through in vivo treatment with the caspase 1/4 inhibitor VX-765 improved disease outcomes associated with greater immune activation and reduced viral burden. HIS models require further refinement to generate lymphoid tissues which more closely recapitulate human tissues, but represent an important tool for discovery and translation for development of HIV interventions

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Retrovirology

ISSN: 1742-4690

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