Fig. 1
From: In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection
Human immune cells are distributed throughout the brains of BLT mice with HIV being present in the brain of infected BLT mice. Immunohistochemical analysis from humanized BLT mice demonstrate the presence of human T cells (hCD3+, green, A) and human macrophages (hCD68+, green, B) in various brain regions. Further brain sections reveal the presence of HIV p24+ cells (red, C) in various brain regions of BLT humanized mice infected with HIV-1CH040 at 2-weeks post-infection. Scale bars: 10 μm. Original magnification at 63x, x2 (insets). FC, frontal cortex; CTX, cortex; HIP, hippocampus; STR, striatum; CRB, cerebellum; MI, midbrain; PO, pons