Fig. 4

HIV-1 interactome pathway analysis. This diagram illustrates the HIV-1 Gag-interacting nuclear host factors discussed in this study. Factors shaded blue were uniquely identified in the present study (newly identified). Proteins shaded in purple were identified in this publication as well as at least one other published report (previously identified). Gray shading was used to show host protein complexes that are involved with Gag-interacting factors in chromatin remodeling, gene expression, nuclear export, and splicing. A HIV-1 Gag interacting factors that promote an open chromatin structure (euchromatin state) are on the left, whereas proteins involved in condensing chromatin are shown on the right. B Proteins involved in regulation of gene expression are depicted. Factors that promote transcription initiation are indicated by arrows and green plus signs. Factors that suppress or inhibit transcription are demarcated by red blocking lines. C The two nucleoporin proteins NUP98 and NUP188 were identified and are involved in trafficking between the nucleus and the cytoplasm through the nuclear pore complex. D Proteins that localize to the spliceosome and are involved in RNA splicing are shown