Fig. 3
From: Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events
Representative lentiviruses exhibit similar configuration of PBS and flanking sequence motifs. Integrase (IN) binding motif fosters cDNA integration to form provirus. Two GAmotifs flank the 5’ splice site that facilitate balanced expression of transcripts that are fully spliced, incompletely spliced and unspliced (US). The initial nucleic acid product of reverse transcription is minus strand strong stop DNA (-SS) that corresponds to the RU5 region of the 3’ long terminal repeat. The products of host transcription and RNA processing are the US and spliced RNAs with UTR length from 293 to 536 nt. aIN binding site; b[number of nts between indicated motifs]; cMinus strand strong stop DNA); dApproximate number of nt between the transcription start site and the gag AUG; eApproximate number of nt between the transcription start site and the 5’ splice site ;fRetrovirus sequence identifiers. HIV-1: NC_001802; Feline immunodeficiency virus: M25381.1; Simian (macaque) immunodeficiency virus, isolate 239: M33262.1; Human immunodeficiency virus 2: NC_001722.1