Fig. 3
From: High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia
(Aus-CS, Aus-DF, Aus-NR, Aus-GM), 11 HTLV-1a genomes (AB513134.1, AB979451.1, AF033817.1, AF042071.1, AF139170.1, HQ606137.1, HQ606138.1, KC807984.1, L03562.2, L36905.1, U19949.1), and one STLV genome (TE4). Sequence gaps were ignored. Colour indicates level of homology, with 100% shown in yellow, and 88% identity shown in dark blue. B Phylogenetic tree analysis on the concatenated 22 Central Australian HTLV-1c genomes generated in this work as well as the 4 HTLV-1c available sequences, shown in purple; the Melanesian HTLV-1c, shown in yellow; Simian, shown in red; and 11 Cosmopolitan HTLV-1a genomes shown in aqua. Outgroup rooting using the STLV-1 sequence was applied, and sequence gaps were ignored. The percentage of trees in which the associated taxa clustered together is shown above the branches. The branch lengths represent the number of substitutions per site. C Nucleotide homology between HTLV-1 subtype-C and subtype-A consensus sequences across the entire 9046Â bp genome. D Percentage similarity of HTLV-1 LTRs and orf gene products between subtype-C and subtype-A consensus sequences. Nucleotide and translated amino acid identities are shown
Australian HTLV-1c genome is highly divergent compared to HTLV-1a. A Pairwise comparisons of the newly assembled Central Australian HTLV-1c genomes (P9-31), the Melanesian HTLV-1c genome (MEL5), 4 previously available Australian HTLV-1c sequences