Fig. 3

Venn diagram of positive HERV loci in CD14 + monocytes from samples obtained from patients after physical trauma or hospitalized from COVID-19. Two scRNA-seq datasets from studies where in vivo activation of CD14 + cells were used: one study that examined the impact of physical trauma while a second study examined patients hospitalized with COVID-19 infections [25, 32] (Supplemental Table 4). A Venn diagram was generated to depict the similarities and differences between the HERV loci detected from each study. From the trauma dataset, 15 discreate HERV loci in patients with physical trauma that were not found in the 10 samples from control individuals. From the COVID patients, 113 discreate loci that were not found in the 6 control subjects (Supplemental Table 5). 10 of the transcribed HERV loci were shared between the trauma and COVID-19 sample sets. The identification of the sites is presented in Supplemental Table 5. The 10 HERV loci that were shared between the two studies are also presented