Fig. 2
From: Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection
The decline in the mRNA expression levels of menin and bach2 in PBMCs from both HAM/TSP and ATL patients. (A) Expression of menin and bach2 mRNA in PBMCs from HTLV-1 infected individuals and normal uninfected controls (NCs) was examined in 21 patients with ATL (acute-type, n = 12; lymphoma-type, n = 6; smoldering-type, n = 2; chronic-type, n = 1), 13 patients with HAM/TSP, 11 ACs, and 11 NCs by qRT-PCR. Statistically significant reduction was observed in the expression level of menin mRNA in both HAM/TSP and ATL patients than NCs. (B) Expression of bach2 mRNA in PBMCs from HTLV-1 infected individuals and NCs was examined by qRT-PCR. The expression level of bach2 mRNA in HTLV-1 infected individuals was significantly lower than were in NCs, irrespective of infection status (i.e., HAM/TSP, ATL, ACs)