Fig. 4
From: Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection
Menin-MLL interaction inhibitor have opposing effects on cell proliferation in two HTLV-1-infected T-cell lines. The effect of the Menin-MLL inhibitor, MI-2-2, on the growth of two types of HTLV-1 infected human T-cell lines, the ATL-derived HTLV-1-infected T-cell line SLB-1 and the HTLV-1-transformed cell line MT-2, was examined. The unfilled, white circle indicates the data with MI-2-2 (12 µM); the filled-in, black circles indicate the data without MI-2-2. (A) MI-2-2 inhibited cell proliferation of MT-2. (B) MI-2-2 did not inhibit cell proliferation of SLB-1