Fig. 5
From: Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection
Knockdown of HTLV-1 Tax by shRNA results in decrease of Bach2 but not Menin protein in HTLV-1-infected T-cell lines. Tax- or HBZ-directed shRNAs in HTLV-1-infected T cell lines showed opposite effects on cell growth by the Menin-MLL interaction inhibitor. The shRNA knockdown of HBZ did not change the expression levels of either Menin and Bach2 in SLB-1 and MT-2 cells (A), whereas the shRNA knockdown of Tax suppressed the expression levels of Bach2 but not Menin in SLB-1 and MT-2 cells (B)