Fig. 6

Knockdown of Menin by siRNA results in decrease of Bach2 in HTLV-1-infected T-cell line MT-2, in which the cell growth is suppressed by Menin-MLL interaction inhibitor. The effect of menin-directed siRNAs in HTLV-1-infected T cell lines showed opposite effects on cell growth to the Menin-MLL interaction inhibitor. The siRNA knockdown of Menin resulted in a decrease of Bach2 in the HTLV-1-infected T-cell line MT-2, in which cell growth was suppressed by the Menin-MLL inhibitor MI-2-2, whereas siRNA knockdown of Menin did not change the expression levels of Bach2 protein in SLB-1 cells, in which cell growth was not affected by the Menin-MLL inhibitor MI-2-2